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Jul 13, 2022

PARKINSON'S! The term alone is enough to scare a lot of old people out there. It is something that affects lots of people and a lot of men every year.


Today we're joined by Jack Jacobs, PhD, President and Chief Science Officer Zhittya Genesis Medicine, Inc. Las Vegas. And we talk about the work they've been doing to treat Parkinson's with their FGF 1 drug.


Jacob educates us about Parkinson's on what it is, how it affects our body and what they've been doing to treat it.


He also tells us about the tests they've been doing and fortunately, they've been seeing positive results there. All this and a lot more in today's interview. Let's jump right in.


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Dr. Jack Jacobs President and Chief Science Officer Zhittya Genesis Medicine, Inc. Las Vegas, NV Dr. Jacobs received his Ph.D. in Molecular Biology from the Washington University School of Medicine, St. Louis where he worked in the lab of Ralph Bradshaw, PhD which was the first lab to isolate and characterize the growth factor, FGF-1. After graduating, he worked at Merck & Co. where he started the Department of Biological Chemistry and was part of the scientific leadership team at Merck. Later, he joined Daniel Montano at CardioVascular BioTherapeutics as their Chief Scientific Officer where he oversaw FDA-authorized clinical trials in which human FGF-1 was tested in a number of medical indications, including coronary artery disease and diabetic foot ulcers. He also supervised all manufacturing activities of FGF-1 for use in the clinical studies. With Zhittya Genesis Medicine, Dr. Jacobs is continuing his efforts on the clinical development of human FGF-1 for a number of medical indications, including neurodegenerative diseases such as Parkinson's disease and ALS (motor neuron disease)


What is Parkinson's Disease

Parkinson's is a progressive, neurodegenerative disorder. In other words, Parkinson's is a lifelong condition that affects the brain and symptoms will get worse over time. Parkinson's happens when cells in the brain that produce dopamine stop working or die. Dopamine is a neurotransmitter, which is a chemical that sends messages between nerve cells or between nerve cells and muscle cells to help the body function. Dopamine plays many roles in the body and affects both physical and mental function.


The cardinal symptoms of Parkinson's are resting tremor, rigidity, slowness of movement (also called bradykinesia) and feeling unsteady and having difficulties with balance (also called postural instability). Because these symptoms are related to movement they are called "motor symptoms" and Parkinson's is classified as a "movement disorder."


However, we now know that Parkinson's also causes "non-motor symptoms." These symptoms include constipation and other gastrointestinal issues, urinary problems, mood changes, sleep disturbances, memory and thinking (cognitive) deficits, sexual problems, excessive sweating, vision problems, and loss of smell or taste. Non-motor symptoms may appear many years before the motor symptoms that eventually lead to a diagnosis.


A bit about me (Dr. Orest Komarnyckyj):

Dr. Orest Komarnyckyj enjoyed a prestigious career as a periodontal regenerative surgeon moving to a new passion in June 2018. He retired after a 33-year career to pursue new passions. At 69 Dr. Orest has taken on a new role as an Interviewer, Podcaster and government-certified Old Guy. He streams from his new home in Las Vegas, NV. He lives with his wife of 29 years, Oksana. His status as an empty-nesters with two out of college-employed children has left him with time and energy to share decades of successes, failures, and wisdom.



00:00 - Precap

00:23 - Intro

01:33 - Guest introduction

03:39 - What's the most important thing you've done today?

04:30 - What do you do at workout? Weights, cardiovascular, or anything else?

05:21 - What causes Parkinsons

07:47 - Dopamine

08:20 - Because of the dopamine decrease, is there depression that's associated with Parkinsons?

08:48 - Why is blood supply important

12:50 - Why exercise is important for old people and people with Parkinson's

14:31 - Do you have a program to keep on course with the exercise program?

15:21 - When you have this increased blood flow into the brain with FGF1, what actually happens?

17:22 - Commercial

17:51 - Commercial ends

18:52 - How long do you talk about seeing some of the aversal of some of the symptoms of Parkinson's and the administration of FGF1?

24:40 - Is FGF 1 available for human use?

27:00 - What other wound healing products does Zhitty Wund Healing BioPharmaceuticals produce and which are available to the public now?

29:50 - Closing thoughts

31:04 - Outro