Nov 20, 2020
Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.
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Dom develops and tests metabolic-based therapies and drugs that target pathways linked pathophysiologically with seizure disorders, neurodegenerative diseases, metabolic dysregulation, cancer and muscle wasting.
Our past and current projects, supported by the Department of Defense (DoD) and Office of Naval Research (ONR), have identified cellular and molecular correlates of CNS oxygen toxicity (CNS-OT) seizures, a phenomenon which limits hyperbaric oxygen therapy and Special Operations (SpecOps) diving.
An emerging area of interest is developing and testing nutritional ketosis (e.g. ketogenic diet, supplementation) and metabolic-based therapies that target cancer metabolism and improve health biomarkers linked to obesity, insulin resistance, type-2 diabetes, longevity and inflammatory-linked diseases.
studies continue to explore the efficacy, mechanism of action and safety of metabolic therapies (ketogenic diet, ketone esters, drugs, etc) with pharmacokinetic and toxicology studies in animal models, with current efforts focused on moving these therapies into human clinical trials.